Science

Abivax's Obefazimod: A (French) Revolution In IBD Treatment

Abivax's Obefazimod: A (French) Revolution In IBD Treatment

Abivax's obefazimod offers a novel oral approach to treat ulcerative colitis by activating miR-124 to downregulate specific pro-inflammatory pathways. Following impressive results in clinical Phase 3 studies, buyout rumors surrounding the French biotech are surging.

Ouster: Building The Interfaces Between AI And The Physical World

Artificial Intelligence

Ouster: Building The Interfaces Between AI And The Physical World

Ouster is positioned to provide essential perception interfaces that allow AI to act within the physical world, as digital LiDAR might become a primary sensory layer for autonomous systems.

Why uniQure’s AMT-130 For Huntington’s Is Not "Too Good To Be True"

Why uniQure’s AMT-130 For Huntington’s Is Not "Too Good To Be True"

Despite impressive Phase I/II AMT-130 results, the FDA views current data as insufficient. Volumetric inclusion criteria may have raised concerns about potential bias. However, analysis indicates the thresholds were sufficiently inclusive, supporting the reported therapeutic effect.

The FDA's Reversal On uniQure's Gene Therapy For Huntington's Is a Disaster For Medical Innovation

The FDA's Reversal On uniQure's Gene Therapy For Huntington's Is a Disaster For Medical Innovation

The FDA’s new restrictive approach to rare disease therapies undermines confidence in regulatory consistency and impedes medical progress. After AMT-130 reduced disease progression by 75% in a phase I/II study, the agency’s reversal threatens to delay a breakthrough.

Why Putting AI Data Centers In Space Doesn’t Make Much Sense

Artificial Intelligence

Why Putting AI Data Centers In Space Doesn’t Make Much Sense

Jeff Bezos said gigawatt AI data centers will orbit Earth in 10 to 20 years. Thermodynamics makes this idea unfeasible. Without convection, waste heat must radiate through panels spanning millions of square metres. Add latency, radiation risks and costs.

uniQure's AMT-130 For Huntington's Is One Giant Leap For Medicine

uniQure's AMT-130 For Huntington's Is One Giant Leap For Medicine

Dutch biotech uniQure's AMT-130 gene therapy shows 75% reduction in Huntington's progression, a breakthrough for this fatal neurodegenerative disease. Success opens path for treating Parkinson's, Alzheimer's or ALS with similar brain-delivered gene therapies.

Quantum Chips: Computing Like A Soap Bubble?

Quantum Chips: Computing Like A Soap Bubble?

Google Quantum AI has made a breakthrough with its Willow quantum chip, demonstrating exponential quantum error correction, suggesting real progress toward reliable quantum computing. However, comparing Willow's performance to conventional computers in the benchmark test used may be misleading.

Abiogenesis III: The RNA World

Abiogenesis III: The RNA World

This article is the third in a series on the origins of life, abiogenesis, chemical evolution, and the RNA world hypothesis.

Abiogenesis II: The Hen Or The Egg?

Abiogenesis II: The Hen Or The Egg?

This article is the second in a series on the origins of life, abiogenesis, chemical evolution, and the RNA world hypothesis.

Abiogenesis I: Sparks Of The Gods And Stardust

Abiogenesis I: Sparks Of The Gods And Stardust

This article is the first in a series on the origins of life, abiogenesis, chemical evolution, and the RNA world hypothesis.

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