Chaotropy

Why uniQure’s AMT-130 For Huntington’s Is Not "Too Good To Be True"

Why uniQure’s AMT-130 For Huntington’s Is Not "Too Good To Be True"

Despite impressive Phase I/II AMT-130 results, the FDA views current data as insufficient. Volumetric inclusion criteria may have raised concerns about potential bias. However, analysis indicates the thresholds were sufficiently inclusive, supporting the reported therapeutic effect.

The AI Bubble Might Pop Even If There Are No “Dark GPUs”

The AI Bubble Might Pop Even If There Are No “Dark GPUs”

Data center GPUs are “melting” under subsidized and unprofitable workloads while circular revenues mask fundamentally unsustainable economics that are increasingly detached from the real world economy. Combined with rising data center related debt, we may now be in the midst of an AI bubble.

The FDA's Reversal On uniQure's Gene Therapy For Huntington's Is a Disaster For Medical Innovation

The FDA's Reversal On uniQure's Gene Therapy For Huntington's Is a Disaster For Medical Innovation

The FDA’s new restrictive approach to rare disease therapies undermines confidence in regulatory consistency and impedes medical progress. After AMT-130 reduced disease progression by 75% in a phase I/II study, the agency’s reversal threatens to delay a breakthrough.

Why AI Could Push Gold To $10,000 Per Ounce By 2030

Innovation & Freedom

Why AI Could Push Gold To $10,000 Per Ounce By 2030

As AI leads us to an age of abundance where machines produce at zero marginal cost, value might shift to genuinely finite assets. With central banks accumulating gold, quantum threats to crypto, and unprecedented monetary expansion, gold could reach $10,000 per ounce by 2030.

Why Putting AI Data Centers In Space Doesn’t Make Much Sense

Artificial Intelligence

Why Putting AI Data Centers In Space Doesn’t Make Much Sense

Jeff Bezos said gigawatt AI data centers will orbit Earth in 10 to 20 years. Thermodynamics makes this idea unfeasible. Without convection, waste heat must radiate through panels spanning millions of square metres. Add latency, radiation risks and costs.

uniQure's AMT-130 For Huntington's Is One Giant Leap For Medicine

uniQure's AMT-130 For Huntington's Is One Giant Leap For Medicine

Dutch biotech uniQure's AMT-130 gene therapy shows 75% reduction in Huntington's progression, a breakthrough for this fatal neurodegenerative disease. Success opens path for treating Parkinson's, Alzheimer's or ALS with similar brain-delivered gene therapies.

OPEN Your Mind

Innovation & Freedom

OPEN Your Mind

Opendoor's impressive rally has drawn meme stock comparisons, but the retail army quickly achieved CEO resignation and demanded strategic change. The company could transform from an iBuyer into an AI-native platform, potentially disrupting America's outdated trillion-dollar real estate market.

Zeta Global Takes Aim At Becoming The Leading AI Marketing Cloud

Innovation & Freedom

Zeta Global Takes Aim At Becoming The Leading AI Marketing Cloud

Zeta Global built a massive consumer data network outside Big Tech, reaching 90% of U.S. adults via AI marketing. Unlike cookie-dependent ad tech, Zeta's model creates compounding advantages: each client adds data that makes the platform smarter for all users, disrupting digital marketing.

Frequency Electronics: From Voyager To The Space Economy

Innovation & Freedom

Frequency Electronics: From Voyager To The Space Economy

Since 1961, Frequency Electronics' precision timing instruments have kept the Voyager and Apollo missions, as well as over 1,000 satellites, synchronized with Earth. With an expected increase in commercial satellites and UAVs, demand for FEIM's atomic clocks is expected to surge.

Verona Pharma: A 363% Return Thanks To Big Pharma's Myopia

Verona Pharma: A 363% Return Thanks To Big Pharma's Myopia

Merck plans to acquire Verona Pharma for $10 billion, or $107 per share — a 363% gain for the Innovation & Freedom Portfolio.

America Was Great When She Was Good

Economy and Society

America Was Great When She Was Good

America must balance protecting her interests while maintaining the moral principles that made her great, or risk losing both her greatness and the world order she created.

The Greatest Bull Trap Of All Time?

The Greatest Bull Trap Of All Time?

The recent market rally seems like a house of cards, built on a single optimistic narrative. The slightest crack in this best-case scenario could trigger a wave of profit-taking, causing the rally to turn into a monumental bull trap.

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